Opana vs. Roxicodone: An In-Depth Comparison

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If you or someone you know is grappling with opioid addiction, it’s essential to delve deeper into the intricacies of different opioids to make informed decisions regarding treatment options. Two commonly prescribed opioids, Opana and Roxicodone, exhibit distinct characteristics that can significantly impact their effects and potential for addiction. In this comprehensive article, we will explore Opana and Roxicodone in detail, aiming to provide you with a thorough understanding of their differences. At OC Revive, our dual diagnosis treatment center in Lake Forest, CA, we offer unwavering support and guidance throughout your recovery journey. To learn more, reach out to us at 844-954-3890.

Active Ingredients and Mechanism of Action:

Let’s begin by examining the active ingredients and their mechanisms of action. Opana contains oxymorphone, a powerful opioid analgesic derived from thebaine, a component of opium. Oxymorphone works by binding to the brain’s opioid receptors, producing pain relief and, in some cases, a feeling of euphoria. Roxicodone, on the other hand, contains oxycodone, another opioid analgesic. Oxycodone also binds to opioid receptors, providing pain relief and, when misused, a sense of euphoria.


One of the fundamental differences between Opana and Roxicodone is their potency. Opana is renowned for its high potency, making it more effective at pain relief even in smaller doses. In contrast, Roxicodone is considered to be less potent, meaning that larger doses are often required to achieve the same level of pain relief. This difference in potency can have profound implications for the risk of addiction and the severity of withdrawal symptoms.

Duration of Action:

Another significant distinction lies in the duration of action of these medications. Opana comes in both immediate-release and extended-release forms, with the latter known as Opana ER. The extended-release formulation provides pain relief over an extended period, reducing the need for frequent dosing. Roxicodone, however, is primarily available in immediate-release tablets, offering rapid pain relief but with a shorter duration of action. This means that Roxicodone may require more frequent dosing to maintain pain relief.

Approved Medical Uses:

Both Opana and Roxicodone are prescribed to manage moderate to severe pain. Physicians may choose one over the other based on the patient’s specific needs. Opana’s extended-release formulation is often employed for patients requiring continuous, around-the-clock pain relief, such as those with chronic pain conditions. Roxicodone, on the other hand, is typically used for immediate pain relief, such as in post-surgical situations.

Risk of Abuse:

The disparity in potency between Opana and Roxicodone plays a significant role in their respective risks of abuse. Opana’s high potency makes it more attractive to individuals seeking intense euphoria, but it also increases the likelihood of addiction when not taken as prescribed. Roxicodone, while still posing a risk of abuse, is considered to be less potent and may be associated with a slightly lower risk of addiction. However, it’s crucial to note that any misuse of opioids carries significant risks.


Apart from potency, another factor to consider is the formulation of these medications. As previously mentioned, Opana is available in both immediate-release and extended-release tablets, offering versatility in pain management. Roxicodone, on the other hand, is primarily available in immediate-release tablets, which means it provides rapid relief but may require more frequent dosing.

Withdrawal Symptoms:

Withdrawal from Opana can be particularly challenging due to its high potency. Individuals who have become dependent on Opana may experience severe withdrawal symptoms, including intense cravings, anxiety, muscle aches, and nausea. Discontinuing Opana should always be done under medical supervision to manage these distressing symptoms. Withdrawal from Roxicodone can also be uncomfortable, but it may be less intense than that associated with Opana.

Treatment Options:

Both Opana and Roxicodone addiction can be effectively treated through comprehensive dual diagnosis programs. These programs, like the ones offered at OC Revive in Lake Forest, CA, address not only substance use but also underlying mental health issues, providing a holistic approach to recovery. The key to successful recovery is seeking professional help and committing to a personalized treatment plan.

Call OC Revive Today!

In conclusion, understanding the differences between Opana and Roxicodone is pivotal for individuals dealing with opioid addiction. Making informed decisions about treatment options can significantly impact the journey to recovery. OC Revive is dedicated to supporting you every step of the way. To take the first step towards a healthier, addiction-free life, contact us at 844-954-3890. Check out our blog where we post weekly on Medium.


Both Opana and Roxicodone carry risks of addiction when used over an extended period. Long-term use should always be carefully monitored by a healthcare professional to ensure safety and effectiveness.

Quitting these opioids abruptly can lead to severe withdrawal symptoms. It is highly recommended to seek medical guidance for a safe and supervised detox and withdrawal process to increase the chances of a successful recovery.

Yes, there are non-opioid pain management options available, ranging from physical therapy to non-opioid medications. Discuss your pain management needs with your healthcare provider to explore alternative treatments that may be more suitable for your condition.

If you suspect a loved one is abusing these medications, express your concern and offer support. Encourage them to seek professional help as soon as possible. Intervention and treatment can make a significant difference in their recovery journey.

To begin the process of seeking help for addiction and mental health challenges at OC Revive, call our dedicated helpline at 844-954-3890. Our experienced team is ready to assist you in finding the right treatment program tailored to your unique needs.

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